Protein Details: Glutamate receptor ionotropic;kainate 2

Protein ID

ICDB_Pro_0818

Protein Name

Glutamate receptor ionotropic;kainate 2

Gene Name

GRIK2; GLUR6

Organism

Homo sapiens (Human)

Length

908 amino acids

AlphaFoldDB

AF-Q13002-F1-model_v4.pdb

Function

Ionotropic glutamate receptor that functions as a cation permeable ligand-gated ion channel;gated by L-glutamate and the glutamatergic agonist kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change;leading to the opening of the cation channel;and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state;characterized by the presence of bound agonist. Modulates cell surface expression of NETO2. In association with GRIK3;involved in presynaptic facilitation of glutamate release at hippocampal mossy fiber synapses (By similarity). Independent of its ionotropic glutamate receptor activity;acts as a thermoreceptor conferring sensitivity to cold temperatures. Functions in dorsal root ganglion neurons (By similarity).

Sequence

MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGKETMA

PDB Structures

3QXM 5CMM

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 516; /ligand="L-glutamate"; BINDING 518; /ligand="L-glutamate"; BINDING 523; /ligand="L-glutamate"; BINDING 689; /ligand="L-glutamate"; BINDING 690; /ligand="L-glutamate"; BINDING 738; /ligand="L-glutamate"

Disease

Neurodevelopmental Disorder With Impaired Language And Ataxia And With Or Without Seizures and Intellectual Developmental Disorder;Autosomal Recessive

Location

Expression is higher in cerebellum than in cerebral cortex

DOI ID

10.1006/geno.1994.1198; 10.1016/s0378-1119(01)00611-4; 10.1016/j.gene.2010.03.002; 10.1038/nature02055; 10.1046/j.1471-4159.1994.63051596.x; 10.1097/00001756-199412000-00055; 10.1113/jphysiol.1996.sp021295; 10.1074/jbc.m109453200; 10.1016/j.bbrc.2003.08.115; 10.4161/cib.19195; 10.1016/j.cell.2019.07.034; 10.1016/j.jmb.2011.08.043; 10.1126/science.1133427; 10.1086/521275; 10.1212/nxg.0000000000000129; 10.1016/j.ajhg.2021.07.007

RefSeq

NP_001159719.1 [Q13002-5]; NP_068775.1 [Q13002-1]; NP_786944.1 [Q13002-2]; XP_005267002.1; XP_011534079.1; XP_011534080.1